And around it we can see in blue the myelin sheath there, and the MOG, if this can be made out, is this little yellow squares that are shown there on that surface and it shows here the MOG antibody going through, so the goal is to be able to test for these in the blood of people and detect them with accuracy in order to avoid both false positive and false negative results which is important in order to make an accurate diagnosis. And here this picture shows that MOG antibody penetrating from the blood into the brain crossing what’s called the blood brain barrier, shown here, and binding to the MOG which is a protein that’s found in the, this is a nerve right here, kind of in this grey-ish color. What we see here is a plasma cell that is making an antibody that is directed against MOG, which is myelin oligodendrocyte glycoprotein. This is the bloodstream is being shown here and showing that there are cells in the blood, types of white blood cells, B cells, that can become what are called plasma cells which are the cells that are the factories that produce antibodies and then release the antibodies into the blood. And so this is a quite complex figure from a paper from Scott Zamvil, but what I would like to highlight here is that in both of these conditions, there are, they’re characterized by the circulation in the bloodstream which we can see kind of at the top here. So, there’ve been already talks today about MOG antibody disease and NMO, but I wanted to focus kind of for the purposes of this talk on the antibodies that characterize these conditions. I’m going to talk today about MOG and aquaporin-4 antibody testing, which is a very important part of a work-up for patients presenting with inflammatory central nervous system conditions in order to make the diagnosis of MOG antibody disease and to characterize patients with neuromyelitis optica. Elias Sotirchos: Great, thank you so much for that introduction, and thank you for the invitation to give this talk today. Sotirchos that we will be able to get to at the end of the presentation, and if you require closed captioning, you can find that in the CC section. And as always, you can submit questions in the Q and A portion for Dr. You can learn, this talk, during this talk you will learn about this testing and its importance in determining a correct diagnosis. There are blood tests that can detect antibodies in some people with MOG antibody disease and neuromyelitis optica spectrum disorder. Sotirchos is a neurologist and Director of the Johns Hopkins Neuromyelitis Optica, Neuromyelitis Optica Center. Elias Sotirchos about understanding MOG and aquaporin-4 antibody testing. Krissy Dilger: Thanks everyone for coming to the RNDS. Connect With SRNA and Request Materials.Quest and LabCorp) by requesting the test codes mentioned above. Testing is available through most hospital laboratories and major reference labs (ie. 95% of cases would require a MOG reflex which would extend the TAT to a total of 10 days or more.ĬNS Demyelinating Disease Evaluation, Serum (AQP4 and MOG) The maximum TAT for the evaluation is 7 days whereas, if performed reflexively, approx. The antibodies are run simultaneously (not reflexed) in order to ensure the highest diagnostic yield while minimizing turn-around-time. The evaluation of both AQP4 and MOG will test for both antibodies simultaneously using a fluorescence-activated cell sorting (FACS) live cell-binding assay which provides optimal sensitivity and specificity in the detection of these antibodies. Patients presenting with sudden vision loss, significant disc edema, or recurrent optic neuritis should consider testing for both MOG and AQP4 antibodies since the combination of these two tests allows for the most comprehensive evaluation for patients recently diagnosed with demyelinating diseases. The test is available as both a stand-alone test (Mayo Test ID: MOGFS) and as part of an evaluation paired with AQP4 (Mayo Test ID: CDS1). MOG antibody testing is now available through Mayo Medical Laboratories.
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